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N useful medicinal compounds NN OS oxazole thiazole NN OS isoxazole isothiazole R2 43 R2 R2 H2, Pd, C NH2 Binar 1 R1OHR1O 5 RN2 1 O or LiAlH4 3,5-disubstituted isoxazole Such heterocycles with even more nitrogen atoms exist but are relatively unimportant and we shall mention just one, the 1,2,5-thiadiazole, because it is part of a useful drug, timolol.

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